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KMID : 1137820120330040207
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의공학회지
2012 Volume.33 No. 4 p.207 ~ p.212
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Effect of Hemiplegia Induced by Sciatic Nerve Injury on both Tibia Trabecular Bone of C57BL/6 Mouse
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Jung Young-Jin
Seo Dong-Hyeon
Kim Han-Sung
Ko Chang-Yong
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Abstract
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It is widely known that sciatic nerve injury (SNI) can negatively affect the biomechanical characteristics of the musculoskeletal system. However, there were no studies that evaluated and compared denervated side with another side limb at the same time. In this study, sixteen male 12-week-old mice were allocated into two groups: HEMI (Right Sciatic nerve denervated) and CON (Control). Both limbs were scanned using micro-CT at 0 week and 4 weeks. There were significant differences in relative variation (RV) of BMD and all structural parameters compared CON and HEMI in right tibia (p < 0.05). Tb.Th and Tb.Sp distributions were differed CON with HEMI in right tibia. In left tibia, there were significant differences in RV of BMD (p < 0.05) and Tb.Sp distribution. These result means that SNI can induce bone loss in the both side tibiae. However, there was a different profile of bone loss between left and right tibiae.
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KEYWORD
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Hemiplegia, Sciatic nerve injury, Trabecular bone, Bone loss
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